Exploiting the promiscuity of imatinib

نویسندگان

Shun J Lee

Jean YJ Wang

چکیده

The protein kinase inhibitor imatinib, also known as Gleevec, has been a notable success in treating chronic myelogenous leukemia. A recent paper in BMC Structural Biology reports a 1.75 A crystal structure of imatinib bound to the oxidoreductase NQO2 and reveals insights into the binding specificity and the off-target effects of the inhibitor.

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Correction: Exploiting the promiscuity of imatinib

This article is available from: http://www.biomedcentral.com/1741-7007/8/82 © 2010 Lee and W ng; licensee BioMed Central Ltd. is an Open Access article distributed u der th terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. BMC ...

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