Can molecular methods detect 1% isoniazid resistance in Mycobacterium tuberculosis?
نویسندگان
چکیده
Patients may harbor both drug-susceptible and -resistant bacteria, representing heteroresistance. We studied mixtures of isoniazid-resistant and -susceptible Mycobacterium tuberculosis strains. Conventional drug susceptibility testing was the most sensitive method of detection, whereas the line probe assay and sequencing were not able to detect the clinically relevant 1% proportion of resistant bacteria.
منابع مشابه
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ورودعنوان ژورنال:
- Journal of clinical microbiology
دوره 51 5 شماره
صفحات -
تاریخ انتشار 2013