Fast P(RMNE): Fast forensic DNA probability of random man not

High throughput sequencing (HTS) of DNA forensic samples is expanding from the sizing of short tandem repeats (STRs) to massively parallel sequencing (MPS). HTS panels are expanding from the FBI 20 core Combined DNA Index System (CODIS) loci to include SNPs. The calculation of random man not excluded, P(RMNE), is used in DNA mixture analysis to estimate the probability that a person is present in a DNA mixture. This calculation encounters calculation artifacts with expansion to larger panel sizes. Increasing the floating-point precision of the calculations allows for increased panel sizes but with a corresponding increase in computation time. The Taylor series higher precision libraries used fail on some input data sets leading to algorithm unreliability. Herein, a new formula is introduced for calculating P(RMNE) that scales to larger SNP panel sizes while being computationally efficient (patent pending). Darrell O. Ricke ( ) Corresponding author: [email protected] : Conceptualization, Data Curation, Formal Analysis, Funding Acquisition, Investigation, Methodology, Project Author roles: Ricke DO Administration, Resources, Software, Supervision, Validation, Visualization, Writing – Original Draft Preparation, Writing – Review & Editing; : Formal Analysis, Investigation, Methodology, Software, Writing – Review & Editing Schwartz S No competing interests were disclosed. Competing interests: Ricke DO and Schwartz S. How to cite this article: Fast P(RMNE): Fast forensic DNA probability of random man not excluded calculation 2017, :2154 (doi: ) [version 1; referees: awaiting peer review] F1000Research 6 10.12688/f1000research.13349.1 © 2017 Ricke DO and Schwartz S. This is an open access article distributed under the terms of the Copyright: Creative Commons Attribution , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Licence This work is sponsored by the Assistant Secretary of Defense for Research & Engineering under Air Force Contract Grant information: #FA8721-05-C-002. Opinions, interpretations, recommendations and conclusions are those of the author and are not necessarily endorsed by the United States Government. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. 20 Dec 2017, :2154 (doi: ) First published: 6 10.12688/f1000research.13349.1 Referee Status: AWAITING PEER REVIEW 20 Dec 2017, :2154 (doi: ) First published: 6 10.12688/f1000research.13349.1 20 Dec 2017, :2154 (doi: ) Latest published: 6 10.12688/f1000research.13349.1 v1 Page 1 of 6 F1000Research 2017, 6:2154 Last updated: 20 DEC 2017