Blood groups and leprosy.
نویسنده
چکیده
The problem of the relation between blood groups and disease has been the subject of many investigations. An important paper appeared as early as 46 years ago (Buchanan and Higley, 1921). Specific studies about blood groups and leprosy also date back to the twenties (Puente, 1927-28 and others). Since that time the relation between the ABO blood groups and this disease has been tested in different countries and at different times. But no one has ever tried to analyse all these data. The importance of this task will be apparent by an inspection of Table I. Not less than 11,261 patients and 390,602 controls have been studied in 14 different countries. An examination of the 27 series listed shows that the only more or less consistent finding is an apparent excess of 0 and lack of B among the leprosy patients as compared with healthy persons. This possible relation was tested by Woolf's (1955) method. The results are listed in the last two columns of Table I. Despite the fact that the incidence of the disease in 0 as compared to B persons is greater than 1 in 16, the deviations are not large and in only two Japanese series do they reach the significance level. The combined analysis of all series shows a total relative O: B incidence negligibly different from unity. The x2 for heterogeneity among the series is on the borderline of significance (x2 = 38&3; 26 d.f.; p > 0.05). An analysis was also tried comparing the incidence of the disease among 0 and non-0 individuals. But here again the relative incidence is practically equal to unity (1 02) and the x2 for heterogeneity shows a significant value (X2 = 55-8; 26 d.f.; p < 0.001).
منابع مشابه
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ورودعنوان ژورنال:
- Journal of medical genetics
دوره 4 2 شماره
صفحات -
تاریخ انتشار 1967