Stimulation of(14C)serotonin synthesis from (14C)tryptophan by mescaline in rat pineal organ cultures.
نویسندگان
چکیده
substrate. Mescaline does not inhibit the deandnation of [14C] serotonin to 5-hydroxyindoleacetic acid and has no significant effect on the intracellular content of [14C] tryptophan or its conversion to [14G] protein. It is • 14 concluded that mescaline stimulates p_ne;¢l [ C] serotonin synthesis via a primary stimula£ory action on the enzymatic conversion of [14.C]tryptophan to 5-hydroxytryptophan, rather than by effects on other steps in the indole pathway or on cellular uptake of [14C] tryptophan.
منابع مشابه
Incorporation of 14C-tryptophan into 14C-protein by cultured rat pineals: stimulation by l-norepinephrine.
Organ cultures of individual rat pineals incorporate (14)C-tryptophan into proteins at a nearly constant rate for at least 48 hours. Previous studies have shown that these cultures also convert (14)C-tryptophan to serotonin, melatonin, and 5-hydroxyindoleacetic acid, and release these indoles into the media. The formation of (14)C-protein from (14)C-tryptophan is accelerated by the addition to ...
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ورودعنوان ژورنال:
- Life sciences. Pt. 2: Biochemistry, general and molecular biology
دوره 10 5 شماره
صفحات -
تاریخ انتشار 1971