Characterisation of the rodent genes for arylacetamide deacetylase, a putative microsomal lipase, and evidence for transcriptional regulation
نویسندگان
چکیده
(‡) Department of Biochemistry and Molecular Biology, University College London, Gower Street, London WC1E 6BT U.K. (||) Lipoprotein Group, MRC Clinical Sciences Centre, Hammersmith Hospital, Ducane Road, London W12 ONN U.K. (¶) Metabolic Research Laboratory, Nuffield Dept of Clinical Medicine, Radcliffe Infirmary, Woodstock Road, Oxford OX2 6HE U.K. (§) To whom correspondence should be addressed +44 207 679 2185 fax +44 207 679 7193 (*) These authors made a similar contribution to this work.
منابع مشابه
Characterization of the rodent genes for arylacetamide deacetylase, a putative microsomal lipase, and evidence for transcriptional regulation.
In the current study, we have determined the cDNA and the genomic sequences of the arylacetamide deacetylase (AADA) gene in mice and rats. The AADA genes in the rat and mouse consist of five exons and have 2.4 kilobases of homologous promoter sequence upstream of the initiating ATG codon. AADA mRNA is expressed in hepatocytes, intestinal mucosal cells (probably enterocytes), the pancreas and al...
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Microsomal arylacetamide deacetylase (DAC) competes against the activity of cytosolic arylamine N-acetyltransferase, which catalyzes one of the initial biotransformation pathways for arylamine and heterocyclic amine carcinogens in many species and tissues. Activity determination and immunoblot analysis of DAC in human target tissues for arylamine carcinogens revealed that in extrahepatic tissu...
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