XWH - 09 - 1 - 0109 TITLE : Histone Code Modulation by Oncogenic PWWP - Domain Protein in Breast Cancers

Award Number : W 81 XWH - 09 - 1 - 0604 TITLE : Histone demethylase GASC 1 as a therapeutic target in basal breast cancer PRINCIPAL

A PWWP Domain of Histone-Lysine N-Methyltransferase NSD2 Binds to Dimethylated Lys-36 of Histone H3 and Regulates NSD2 Function at Chromatin.

The readout of histone modifications plays a critical role in chromatin-regulated processes. Dimethylation at Lys-36 on histone H3 (H3K36me2) is associated with actively transcribed genes, and global up-regulation of this modification is associated with several cancers. However, the molecular mechanism by which H3K36me2 is sensed and transduced to downstream biological outcomes remains unclear....

W 81 XWH - 09 - 1 - 0639 TITLE : Progesterone Receptor Scaffolding Function in Breast Cancer

XWH - 04 - 1 - 0542 TITLE : D 2 as an Integrator of Oncogenic Stimuli in Breast Cancer

Award Number : W 81 XWH - 09 - 1 - 0615 TITLE : Novel Antimicrotubule Agents For Breast Cancer PRINCIPAL