TRANSLATIONAL PHYSIOLOGY Genetic susceptibility to S. aureus mastitis in sheep: differential expression of mammary epithelial cells in response to live bacteria or supernatant
نویسندگان
چکیده
Cécile M. D. Bonnefont, Pascal Rainard, Patricia Cunha, Florence B. Gilbert, Mehdi Toufeer, Marie-Rose Aurel, Rachel Rupp, and Gilles Foucras Université de Toulouse, Institut National Polytechnique (INP), École Nationale Vétérinaire de Toulouse (ENVT), Unité Mixte de Recherche (UMR)1225, Interactions Hôtes Agents Pathogènes (IHAP); Institut National de la Recherche Agronomique (INRA), UMR1225, IHAP, Toulouse; INRA, Unité de Recherche (UR) 631, Station d’Amélioration Génétique des Animaux (SAGA), Castanet-Tolosan; INRA, UR1282, Infectiologie et Santé Publique (ISP), Nouzilly; Université François Rabelais de Tours, UMR 1282, ISP, Tours; and INRA, Unité Expérimentale 321, Domaine expérimental de La Fage, Roquefort, France
منابع مشابه
Genetic susceptibility to S. aureus mastitis in sheep: differential expression of mammary epithelial cells in response to live bacteria or supernatant.
Staphylococcus aureus is a prevalent pathogen for mastitis in dairy ruminants and is responsible for both clinical and subclinical mastitis. Mammary epithelial cells (MEC) represent not only a physical barrier against bacterial invasion but are also active players of the innate immune response permitting infection clearance. To decipher their functions in general and in animals showing differen...
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Background: Staphylococci are recognized worldwide as one of the most important etiological agents of bovine mastitis due to their virulence factors such as their ability to penetrate inside mammary epithelial cells and their ability to form biofilm. Aims: The objectives of this study were to establish a model of primary mammary epithelial cells origin...
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Staphylococci isolated from 98 mastitic cow’s milk samples were analyzed for the production of alpha,beta and delta-hemolysin on sheep, bovine and horse red blood cells and in vitro susceptibility to several antimicrobial agents. Out of a total of 18 isolated strains, 100% demonstrated hemolytic activity either alone or in combined forms. Among 8 isolates of S. aureus 3 isolates produced α/β an...
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Four-hundred milk samples from half udders of 20 flocks of native breed goats were asepticallycollected. The samples were examined by California mastitis test (CMT). Twenty-one (5.25%) of 400 wereCMT-positive. The CMT-positive samples were then cultured and the following bacteria were isolated:Staphylococcus aureus in 3 (14.28%), CNS (coagulase-negative staphylococci) in 14 (66.66%), streptococ...
متن کاملImmune relevant gene expression of mammary epithelial cells and their influence on leukocyte chemotaxis in response to different mastitis pathogens
Different mastitis pathogens induce different courses of infection, i.e. more or less severe. Mammary epithelial cells play an important role in the initial combat against microorganisms by expression of cytokines and acute phase proteins that regulate the immune response. The objective of the present study was to investigate the involvement of the epithelial cells into the outcome of mastitis ...
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