Lack of motor progression in isolated sensory peripheral neuropathy.

(EMG) studies are critical for the detection, diagnosis, and characterization of peripheral neuropathy (PN). Although NCS and EMG abnormalities are often compared to clinical findings, these data are not always concordant. Examples of this discordance include patients with small fiber PN having severe deficits of nociceptive and thermal function but normal NCS1, or patients with Charcot-Marie-Tooth disease type 1Awith minimal symptoms but florid NCS changes2,3. The utility of using NCS/EMG for prediction of later clinical outcomes is also unclear in many forms of PN4-6. We prospectively identified and followed patients with isolated sensory PN (ISPN) based upon a lower limb stocking pattern of sensory loss for nociception, thermal sensation, vibration threshold and/or proprioception with initially normal motor strength, tone, reflexes and muscle bulk. The objective of this study was to determine if patients with initial ISPN go on to develop clinical and or electrophysiologic progression of motor deficits.