Maternal Protein Restriction Compromises Myocardial Contractility 3 in the Young Adult Rat by Changing Proteins Involved in Calcium
نویسندگان
چکیده
TITLE PAGE 1 2 MATERNAL PROTEIN RESTRICTION COMPROMISES MYOCARDIAL CONTRACTILITY 3 IN THE YOUNG ADULT RAT BY CHANGING PROTEINS INVOLVED IN CALCIUM 4 HANDLING 5 6 7 Aucelia C. S. de Belchior; David D. Freire Jr; Carlos P. da Costa; Dalton V. Vassallo; Alessandra 8 S. Padilha ; Leonardo dos Santos * 9 10 Department of Physiology and Pharmacology, Federal University of Pernambuco, Recife, PE, Brazil 11 Department of Physiological Sciences, Federal University of Espirito Santo, Vitória, ES, Brazil 12 Department of Physiological Sciences, EMESCAM, Vitória, ES, Brazil 13 14 15 Running head: MPR and myocardial contractile dysfunction in the offspring 16 17 18 19 *Corresponding author (Leonardo dos Santos, MD, PhD) 20 Email: [email protected] 21 Address: Programa de Pós-Graduação em Ciências Fisiológicas, CCS/UFES. Av. Marechal 22 Campos, 1468. Maruípe. 29040-091, Vitoria, ES, Brasil. FAX: 55-27-2122-7330. 23 Articles in PresS. J Appl Physiol (November 19, 2015). doi:10.1152/japplphysiol.00246.2015
منابع مشابه
Maternal protein restriction compromises myocardial contractility in the young adult rat by changing proteins involved in calcium handling.
Maternal protein restriction (MPR) during pregnancy is associated with increased cardiovascular risk in the offspring in adulthood. In this study we evaluated the cardiac function of young male rats born from mothers subjected to MPR during pregnancy, focusing on the myocardial mechanics and calcium-handling proteins. After weaning, rats received normal diet until 3 mo old, when the following p...
متن کاملExpressions of CD11a, CD11b, and CD11c integrin proteins in rats with myocardial hypertrophy
Objective(s):To examine the expressions of CD11a, CD11b, and CD11c integrins in the myocardial tissues of rats with isoproterenol-induced myocardial hypertrophy. This study also provided morphological data to investigate the signal transduction mechanisms of myocardial hypertrophy and reverse it. Materials and Methods: A myocardial hypertrophy model was established by subcutaneously injecting i...
متن کاملProtein Drug Targets of Lavandula angustifolia on treatment of Rat Alzheimer᾽s Disease
Different treatment strategies of Alzheimer's disease (AD) are being studied for treating or slowing the progression of AD. Many pharmaceutically important regulation systems operate through proteins as drug targets. Here, we investigate the drug target proteins in beta-amyloid (Aβ) injected rat hippocampus treated with Lavandula angustifolia (LA) by proteomics techniques. The reported study sh...
متن کاملProtein Drug Targets of Lavandula angustifolia on treatment of Rat Alzheimer᾽s Disease
Different treatment strategies of Alzheimer's disease (AD) are being studied for treating or slowing the progression of AD. Many pharmaceutically important regulation systems operate through proteins as drug targets. Here, we investigate the drug target proteins in beta-amyloid (Aβ) injected rat hippocampus treated with Lavandula angustifolia (LA) by proteomics techniques. The reported study sh...
متن کاملSpasmolytic Effect of Stachys Lavandulifolia Vahl. Crude Methanolic Extract and Fractions on Rat Ileum
The aim of this study was to investigate the effect of aerial parts of Stachys lavandulifolia Vahl. extract on the rat ileum contractions. The crude extract was prepared by maceration method (90% methanol) followed by fractionating into chloroform, ethyl acetate, petroleum ether and water. In adult male Wistar rats, ileum was sectioned and mounted in tissue bath and their contractility was reco...
متن کامل