Topiramate associated hypohidrosis and hyperthermia.
نویسندگان
چکیده
Topiramate is a new antiepileptic drug, used for treatment of partial onset seizure and refractory seizures. Although it is well tolerated in children, some adverse effects including hypohidrosis and hyperthermia are reported. We present two children with epilepsy who were treated with topiramate and developed hypohidrosis and hyperthermia.
منابع مشابه
Hypohidrosis and hyperthermia during topiramate treatment in children.
Topiramate is one of the newer generation antiepileptic drugs with a beneficial clinical effect on various seizure types. In this study, we present the clinical findings of hypohidrosis and hyperthermia with topiramate in pediatric patients. The data were collected retrospectively on 173 patients diagnosed as epilepsy on topiramate treatment, and hypohidrosis-related symptoms induced by topiram...
متن کاملTopiramate-induced severe heatstroke in an adult patient: a case report
BACKGROUND Heatstroke is a life-threatening condition defined by failure of heat load dissipation, resulting in a core temperature higher than 40 °C (104 °F) associated with neurological dysfunction. Topiramate may cause anhidrosis, potentially resulting in heatstroke, as reported especially in children. CASE PRESENTATION A 57-year-old Caucasian man was admitted to the emergency room in a feb...
متن کاملBlue pseudochromhidrosis secondary to topiramate treatment.
© 2009 The Authors. doi: 10.2340/00015555-0696 Journal Compilation © 2009 Acta Dermato-Venereologica. ISSN 0001-5555 Sir, Topiramate (TPR) is an adjunctive treatment for patients with refractory epilepsy. Several cases of hypohidrosis under TPR treatment have been reported. We describe here a new reversible side-effect on human sweating function: blue pseudochromhidrosis. Chromhidrosis and pseu...
متن کامل[Heat stroke related to the use of topiramate. The importance of prevention].
Heat stroke is the most severe pathology related to heat. It is defined as an increase in core body temperature accompanied by signs of neurological dysfunction. In the absence of an early treatment, it has a very high mortality rate. Topiramate is a well known drug widely used in epilepsy treatment and migraine prevention. Oligohydrosis has been described amongst topiramate side effects, favou...
متن کاملA new method for the preparation of pure topiramate with a micron particle size
Crude topiramate was prepared from the reaction between diacetonefructopyranose, sulfuric diamide, and 2-picoline. During a controlled processing the presence of Triton-X-100, crude topiramate in a methanol-water solvent, was converted to pure micron size topiramate particles. The factors affecting the purification and micronization of topiramate, such as solvent and anti-solvent type and conce...
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ورودعنوان ژورنال:
- Indian pediatrics
دوره 45 3 شماره
صفحات -
تاریخ انتشار 2008