Antinociceptive Activity of Ethanolic Neem (Azadirachta Indica) Leaf Extract (Enle) Through Opioid Pathway in Adult Rats

نویسنده

  • Meenakshi Maurya
چکیده

Pain is an unpleasant though very important protective mechanism [1]. It is usually associated with actual or potential tissue damage and is primary reason for seeking medical attention [2]. Opioids are one of the most efficacious analgesics for moderate to severe pain [3]. But they possess strong addictive potential and various other side effects like respiratory depression, drowsiness etc [4]. Therefore, analgesic drugs which lack these side effects as an alternative are need of time [1].

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Ethanolic Neem (Azadirachta indica) Leaf Extract Prevents Growth of MCF-7 and HeLa Cells and Potentiates the Therapeutic Index of Cisplatin

The present study was designed to gain insight into the antiproliferative activity of ethanolic neem leaves extract (ENLE) alone or in combination with cisplatin by cell viability assay on human breast (MCF-7) and cervical (HeLa) cancer cells. Nuclear morphological examination and cell cycle analysis were performed to determine the mode of cell death. Further, to identify its molecular targets,...

متن کامل

Ethanolic neem (Azadirachta indica) leaf extract induces apoptosis in the hamster buccal pouch carcinogenesis model by modulation of Bcl-2, Bim, caspase 8 and caspase 3.

Induction of apoptosis is one of the most active strategies in cancer chemoprevention and the ability of medicinal plants in this regard has attracted major research interest. The present study was designed to investigate the apoptosis inducing capacity of an ethanolic neem leaf extract (ENLE) during 7,12-dimethylbenz[a]anthracene (DMBA)-induced hamster buccal pouch carcinogenesis using the apo...

متن کامل

Ethanolic extract of Melia Azadirachta against Acetaminophen induced Nephrotoxicity

Aim of the study is to investigate the Nephroprotective activity of ethanolic extract taken from Melia azadirachta leaves, against APAP (Acetaminophen) induced nephrotoxicity. The phytochemical screening was carried out on the leaf extracts of Melia azadirachta, revealed the presence of active ingredients such as Phytol, Squalene, Oleic Acid, 2-Piperidinone, N-[4-bromo-n-butyl]. Leaves of Melia...

متن کامل

Effect of Neem Leaf Extract (Azadirachta indica) on c-Myc Oncogene Expression in 4T1 Breast Cancer Cells of BALB/c Mice

OBJECTIVE Breast cancer is the most common cause of cancer-related deaths in women both worldwide and in Malaysia. Azadirachta indica (A. Juss), commonly known as neem, is one of the most versatile medicinal plants that has gained worldwide prominence due to its medicinal properties. However, the anticancer effect of ethanolic neem leaf extract against breast cancer has not been documented. The...

متن کامل

Efficacy of plant extracts on the toxicity, ovipositional deterrence and damage assessment of the cowpea weevil, Callosobruchus maculatus (Coleoptera: Bruchidae)

A laboratory experiment was conducted to investigate the efficacy of different plant derivatives against the development of the cowpea weevil, Callosobruchus maculatus (F) (Coleoptera: Bruchidae) fed on cowpea, Vigna unguiculata (W) seeds. The leaf extracts of romatic plants, Murraya koenigii and Azadirachta indica (A.Juss) were evaluated for their growth, adult mortality and oviposition inhibi...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:

دوره   شماره 

صفحات  -

تاریخ انتشار 2017