Cholestasis and Fibrosis Lymphocyte Function but Modulate Liver Regulatory T Cells, Which Impair Liver T Obstructive Jaundice Expands Intrahepatic
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Cholestatic jaundice in infancy. The importance of familial and genetic factors in aetiology and prognosis.
One hundred and twenty-four infants admitted to hospitals in Norway between 1955 and 1974 during the first 3 months of life with cholestatic jaundice were studied retrospectively. Sixty-four infants had had extrahepatic atresia of the biliary tree and 60 had had intrahepatic cholestasis. This gives an incidence of about 1:9000 live births for cholestasis. In 4 of the 64 infants with extra-hepat...
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OBs-mucTivF jaundice is amenable to surgical treatment when the obstruction is extrahepatic. In recent years it has been recognised that the obstruction may be intrahepatic and the complete picture of obstructive jaundice may be seen without obstruction of the main bile ducts. It is important to differentiate between intrahepatic anid extrahepatic cholestasis in order to avoid unnecessary surgi...
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Obstructive jaundice is associated with immunologic derangements and hepatic inflammation and fibrosis. Because dendritic cells (DCs) play a major role in immune regulation, we hypothesized that the immunosuppression associated with jaundice may result from the functional impairment of liver DCs. We found that bile duct ligation (BDL) in mice expanded the myeloid subtype of liver DCs from 20 to...
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The normal liver is characterized by immunologic tolerance. Primary mediators of hepatic immune tolerance are liver sinusoidal endothelial cells (LSECs). LSECs block adaptive immunogenic responses to Ag and induce the generation of T regulatory cells. Hepatic fibrosis is characterized by both intense intrahepatic inflammation and altered hepatic immunity. We postulated that, in liver fibrosis, ...
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SYNOPSIS Oral contraceptives can cause liver damage and jaundice but this is very rare in women in the United Kingdom. The drugs are contraindicated where there is a history of recurrent intrahepatic cholestasis of pregnancy and acute or chronic disturbance of liver function which can be congenital or acquired. It is not yet known whether the oestrogenic or progestogenic components of oral cont...
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