Systemic Safety of Pegaptanib Sodium in the Treatment of Age - Related Macular Degeneration ( AMD ) in Subjects with Diabetes Mellitus ( DM ) : A Pooled Analysis

submission. Results: Nine eyes from nine patients were included in this study. Mean follow-up was 9.2 months (3-20 months). These patients received a mean of 5.3 injections (35 lucentis, 13 avastin) within the 12 months prior to declaration of treatment failure. After rescue combination therapy, a mean of 1.9 retreatments were administered (13 lucentis, 6 avastin, 4 combination retreatments). At one month after combination treatment, subretinal or intraretinal fluid resolved completely in 4 eyes, improved in 3 eyes and was unchanged in 2 eyes. Mean visual acuity was .85 logmar (20/140) before rescue therapy, .70 (20/100) at one month, and .75 (20/1002) at 3 months. The mean interval between injections increased from 2.3 months to 3.89 months after combination therapy. Conclusions: Rescue therapy with the combination of Anti-VEGF and PDT is effective for eyes which fail Anti-VEGF monotherapy. Most patients experienced a decrease in subretinal fluid, improvement in visual acuity, and longer period between injections after patients receive combination therapy. Larger studies are needed to confirm these results. Commercial Relationships: Kevin R. Tozer, None; Lawrence Chong, None; Srinivas R. Sadda, None