Two-year outcome of a randomized trial comparing second-generation drug-eluting stents using biodegradable or durable polymer.

نویسندگان

  • Masahiro Natsuaki
  • Ken Kozuma
  • Takeshi Morimoto
  • Hiroki Shiomi
  • Takeshi Kimura
چکیده

Two-Year Outcome of a Randomized Trial Comparing Second-Generation Drug-Eluting Stents Using Biodegradable or Durable Polymer Recentnetworkmeta-analyseshave raisedconcerns about the safety of biodegradable polymerdrug-eluting stents (BP-DES) compared with durable polymer everolimus-eluting stents (DP-EES).1-3 The NOBORI Biolimus-Eluting vs XIENCE/ PROMUSEverolimus-ElutingStentTrial (NEXT) is a98-center, randomized, open-label, noninferiority trial evaluating theefficacy and safety of biodegradable polymer biolimus-eluting stents (BP-BES) vs DP-EES.4 Theprimary efficacyoutcomeof target-lesion revascularization (TLR) at 1 year demonstratednoninferiority of BP-BES comparedwithDP-EES.4 Theprimary safety outcome, a composite of death and myocardial infarction (MI), will be reported at 3 years.However, because the advantages ofBP-BES could emerge beyond 1 year when polymer has fully degraded, we report the interim 2-year results.

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عنوان ژورنال:
  • JAMA

دوره 311 20  شماره 

صفحات  -

تاریخ انتشار 2014