Enantio- and diastereoselective palladium catalysed arylative and vinylative allene carbocyclisation cascades.
نویسندگان
چکیده
The enantioselective synthesis of heavily decorated spirolactams has been accomplished via an arylative or vinylative allene carbocyclisation cascade. Mediated by silver phosphate, a range of allene-linked pro-nucleophiles and aryl or vinyl iodides were reacted in the presence of catalytic Pd(OAc)2 and chiral bis(oxazoline) ligands to afford the spirolactam products in good yields and high enantio- and diastereoselectivities.
منابع مشابه
A diastereoselective carbocyclisation of allene-hydrazones through the intramolecular allylic transfer reaction.
A diastereoselective synthesis of cyclic hydrazines was achieved from a carbocyclisation of allene-hydrazones by the Pd-catalyzed distannylation of an allene moiety, followed by the transmetallation of allylic stannane intermediates with TiCl4.
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ورودعنوان ژورنال:
- Chemical communications
دوره 49 46 شماره
صفحات -
تاریخ انتشار 2013