Computational Model of Ductal Carcinoma In Situ: The Effects of Contact Inhibition on Pattern Formation
نویسندگان
چکیده
The computational model presented in this paper focuses on modeling ductal carcinoma in situ (DCIS), which is the most commonly detected preinvasive form of breast cancer. The model aims to understand the biological mechanisms and resultant growth dynamics of DCIS. The cellular automaton model based on observed phenotypic characteristics of DCIS emphasize the important role of contact inhibition on lesion pattern formation. Computer simulations resembled the cribriform, micropapillary, solid, and comedo patterns of DCIS. The model has led to insights about the progression of the preinvasive disease such as possible explanations for coexisting micropapillary and cribriform patterns commonly found through histological analyses.
منابع مشابه
Computational Model of Ductal Carcinoma In-Situ
Breast cancer, when found in its early stages, is a manageable disease. When detected, biopsied, and diagnosed, lesions such as ductal carcinoma in-situ (DCIS) or invasive ductal carcinoma (IDC) are promptly removed. Consequently, the natural history of DCIS and IDC in-vivo is not well known. DCIS manifests itself with various distinctive patterns and pathologies. In order to study the growth d...
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ورودعنوان ژورنال:
- IEEE transactions on bio-medical engineering
دوره 56 5 شماره
صفحات -
تاریخ انتشار 2009