Development of Dengue Vaccine
نویسنده
چکیده
The dengue viruses are estimated to cause several hundred thousand cases of dengue fever, dengue haemorrhagic fever and dengue shock syndrome annually. Attempts to prevent the infection focus on the development of a vaccine that would protect against all four serotypes of the dengue virus. Various biotechnological approaches are being explored, including the use of live attenuated or inactivated viruses, infectious clone-derived vaccines, immunogens vectored by various recombinant systems, subunit immunogens and nucleic acid vaccine. Three candidate vaccines are undergoing clinical evaluation and several are at the stage of pre-clinical evaluation. A WHO steering committee is conducting activities aimed at accelerating the development of vaccines against dengue and Japanese encephalitis.
منابع مشابه
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