Nickel-catalyzed decarbonylative alkylidenation of phthalimides with trimethylsilyl-substituted alkynes.

نویسندگان

  • Takahiro Shiba
  • Takuya Kurahashi
  • Seijiro Matsubara
چکیده

We have developed a nickel-catalyzed transformation, in which phthalimides react with trimethylsilyl-substituted alkynes in the presence of Ni(0)/PMe3/MAD catalyst to provide isoindolinones. The reaction process displays an unusual mechanistic feature-decarbonylation and alkylidenation. The use of both trimethylsilyl-substiuted alkynes and MAD was found to be essential for the transformation with high selectivities.

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عنوان ژورنال:
  • Journal of the American Chemical Society

دوره 135 37  شماره 

صفحات  -

تاریخ انتشار 2013