The Molecular Clock of Neurospora crassa
نویسنده
چکیده
1988 Ph.D. University of Heidelberg, Germany 1989 1991 PostDoc Princeton University and Rockefeller Research Laboratory, New York, USA (Prof. James E. Rothman) 1992 1998 Group Leader and habilitation Ludwig-MaximiliansUniversität München, Germany (Prof. Walter Neupert) 1998 2000 Professor Ludwig-Maximilians-Universität München, Germany since 2000 Full Professor BZH 2010 2013 Director BZH
منابع مشابه
MOLECULAR ANALYSIS OF THE SULFUR REGULATORY CIRCUIT OF NEUROSPORA CRASSA
The sulfur regulatory circuit of the filamentous fungus, Neurospora crassa, consists of a set of unlinked structural genes which encode sulfur catabolic and two major regulatory genes which govern their expression. The cys-3 regulatory gene encode a transacting regulatory protein which activates the expression of cys-14 and ars, whereas the other regulatory genes Scon-l and Scon-2 appear to...
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Neurospora crassa is the only molecular genetic model system for circadian rhythms research in the fungi. Its strengths as a model organism lie in its relative simplicity--compared to photosynthesizing and vertebrate organisms, it is a stripped-down version of life. It forms syncitial hyphae, propagates and reproduces, and the circadian clock is manifest in numerous processes therein. As with o...
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Neurospora crassa is a filamentous fungus and a model organism for the study of the molecular basis of circadian clocks. Rhythmic sporulation of this organism is maintained for prolonged periods in the dark with a periodicity of approximately 22 h. Three genes; frequency, white collar-1 and white collar-2, and their associated kinases and phosphatases, are key components of the circadian clock ...
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At first, the saprophytic eukaryote Neurospora crassa and the photosynthetic prokaryote Synechococcus elongatus may seem to have little in common. However, in both organisms a circadian clock organizes cellular biochemistry, and each organism lends itself to classical and molecular genetic investigations that have revealed a detailed picture of the molecular basis of circadian rhythmicity. In t...
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Circadian clocks are self-sustaining timekeepers found in almost all organisms on earth. The filamentous fungus Neurospora crassa is a preeminent model for eukaryotic circadian clocks. Investigations of the Neurospora circadian clock system have led to elucidation of circadian clock regulatory mechanisms that are common to all eukaryotes. In this work, we will focus on the Neurospora circadian ...
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The ability of Neurospora crassa FGSC 4335 in the biotransformation of hydrocortisone was investigated. The microorganism produced two major metabolites after incubation with the substrate for seven days. Each microbial product was purified chromatographically and identified on the basis of spectral data. The products were identified as 11?,17?,20?,21-tetrahydroxypregn-4-en-3-one (II) and 11?-h...
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