Atlas of Genetics and Cytogenetics in Oncology and Haematology
نویسنده
چکیده
Caspase-8 belongs to the family of cysteine proteases that plays a critical role in the regulation of programmed cell death (apoptosis). For example, caspase-8 function is required for proper signaling via the death receptor (extrinsic) pathway. Accordingly, the disturbance of caspase-8 expression or function may contribute to cancer formation and progression. In addition, inactivation of caspase-8 may promote resistance to current treatment approaches, which critically require signaling via the death receptor pathway. Thus, restoration of caspase8 function presents a promising approach to overcome resistance to apoptosis in human cancers.
منابع مشابه
SERPINB3 (serpin peptidase inhibitor, clade B (ovalbumin), member 3).
Review on SERPINB3, with data on DNA/RNA, on the protein encoded and where the gene is implicated.
متن کاملAtlas of Genetics and Cytogenetics in Oncology and Haematology, an Interactive Database
The 'Atlas of Genetics and Cytogenetics in Oncology and Haematology' (http://www.infobiogen.fr/services/chromcancer ) is a database devoted to chromosome abnormalities in cancer, cancer-prone diseases and genes involved in cancer. Information presented in each page is concise and updated. This database is made for and by: cytogeneticists, molecular biologists, clinicians in oncology and in haem...
متن کاملAtlas of Genetics and Cytogenetics in Oncology and Haematology, year 2003
The 'Atlas of Genetics and Cytogenetics in Oncology and Haematology' (http://www.infobiogen.fr/services/chromcancer) contains concise and updated cards on genes involved in cancer, cytogenetics and clinical entities in oncology, and cancer-prone diseases, a portal towards genetics/cancer, and teaching materials in genetics. This database is made for and by researchers and clinicians, who are en...
متن کاملAtlas of Genetics and Cytogenetics in Oncology and Haematology, updated
The 'Atlas of Genetics and Cytogenetics in Oncology and Haematology' (http://www.infobiogen.fr/services/chromcancer) is an Internet database aimed at genes involved in cancer, cytogenetics and clinical entities in cancer, and cancer-prone diseases. It presents information in concise and updated reviews (cards) or longer texts (deep insights), a (new) case report section, a huge portal towards g...
متن کاملNMT1 (N-myristoyltransferase 1).
Department of Pathology and Laboratory Medicine, College of Medicine, University of Saskatchewan, Saskatoon, SK S7N OW8, Canada (PS, SK, RKS); Cancer Research Unit, Saskatchewan Cancer Agency, 20 Campus Drive, Saskatoon, SK S7N 4H4, Canada (PS, SK, RKS); Drug Design and Discovery Research Group, College of Pharmacy and Nutrition, University of Saskatchewan, Saskatoon, Saskatchewan S7N 5C9, Cana...
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