Medicinal chemistry from fungi and back: discovery of novel anti-fungal drugs and mycotherapy of cancer and other diseases with fungal metabolites.
نویسندگان
چکیده
Fungi are important organisms for human population and could find important applications namely, in many pharmaceutical and food industries. A variety of compounds has been isolated from medicinal and edible mushrooms, and their healthbeneficial effects have been reported. On the other hand, it is important to control microfungi as parasites and contaminants since they can provoke, in some cases, serious issues to human health.
منابع مشابه
بررسی آزمایشگاهی فعالیت ضدمیکروبی عصارههای آبی و الکلی سلمک و درمنه ترکی بر کاندیدا آلبیکنس
Background & Objectives: In recent decades, rate of infections caused by opportunistic fungi, such as Candida albicans, has increased dramatically. Treatment of fungal diseases is associated with limitations such as rare and expensive antifungal drugs and their side effects, drug resistance and reduced susceptibility of fungi to drugs. Therefore, researchers have been concerned with finding new...
متن کاملSynthesis and evaluation of the antifungal effects of [5-aryl-[1, 3, 4] oxadiazole-2-yl] phenyl-methanol
Introduction: Nowadays the drug resistance outbreak in fungi is considered a serious threat to the health of human societies. Oxadiazole derivatives that are high biologically applicable can be a good alternative to common anti-fungal drugs. The purpose of this study was to evaluate the anti-fungal properties of new derivatives synthesized of oxadiazole and compare them with common anti-fungal ...
متن کاملRNAi technology: A Novel approaches against fungal infections
Despite the introduction of new antifungal agents, resistances to antifungal therapy continue to increase and outcome of invasive fungal infections treatment is frequently suboptimal. A large amount of the recent effort in antifungal drug discovery has focused on a limited set of targets with functions known or expected to be important for fungal viability and virulence. A variety of techniques...
متن کاملEndophytic Chaetomium sp. from Michelia champaca L. and its taxol production
The study of naturally occurring compounds from plants has progressed to its present state of development by passing through a long time. Fungi have an excellent record in producing novel bioactive compounds and many of these presently have important medicinal properties. We subsequently isolated few endophytic fungi from plant parts and tested for the production of taxol like compound. Medicin...
متن کاملمروری بر دارورسـانی موضـعی داروهای ضـدقارچ و مقایسهی فرمهای مرسوم با سیستمهای نوین دارورسانی
Fungi are eukaryotic organisms that potentially have the ability to cause disease in humans and animals. Fungal infections are called mycosis, which are divided into four types of superficial, cutaneous, subcutaneous and systemic, depending on the area of the body involved. Though cutaneous mycoses are rarely life-threatening infections, they can isolate the patient socially due to the disfig...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Current topics in medicinal chemistry
دوره 13 21 شماره
صفحات -
تاریخ انتشار 2013