Acute heart failure syndromes
نویسنده
چکیده
Heart failure resulting in hospitalization represents a significant and growing health care burden. Heterogeneity characterizes this group in terms of mode of presentation, pathophysiology, and prognosis. The vast majority of patients symptomatically improve during hospitalization; however, their early post-discharge rehospitalization and mortality rates continue to be high. Worsening signs and symptoms, neurohormonal, and renal abnormalities occurring soon after discharge may contribute to these high post-discharge event rates. Currently available assessment modalities combined with recent advances in cardiovascular therapies provide present-day opportunities to improve post-discharge outcomes. Further investigation into pathophysiologic targets and novel approaches to clinical trial design are needed. Improving post-discharge outcomes is the single most important goal in the management of acute heart failure syndromes.
منابع مشابه
Classification of patients with acute heart failure syndromes in the emergency department.
Hospitalization for acute heart failure syndromes (AHFS) heralds a grim prognosis: More than one third of patients will be dead or rehospitalized within 90 days postdischarge.1 Although total hospitalizations for AHFS have decreased over the past decade, rehospitalization rates have not.2,3 With 1 million hospitalizations annually at an estimated cost exceeding $20 billion, AHFS is a major publ...
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Hospitalization for acute heart failure syndromes (AHFS) is a growing health care burden. Over 1 million hospitalizations occur annually, with a postdischarge mortality and rehospitalization rate of ~45% by 90 days and a financial cost greater than $20 billion. Attempts to improve outcomes through novel therapies have largely failed, suggesting new approaches are needed. We review phase II stud...
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