Ion Selective Electrodes for Determination of Cefditoren Pivoxil in Pharmaceutical Formulations and Biological Fluids

Newly developed coated wire electrodes have been developed for determination of cefditoren pivoxil (CTP) in pure form, pharmaceutical preparations and in biological fluids. The selective electrodes were fabricated based on the incorporation of cefditoren pivoxil with the ion exchangers, phosphomolybdic acid (CTP-PMA), phosphotungstic acid (CTP-PTA) and a mixture of both (CTP-PMA/PTA). The potential responses of the electrodes were influenced by the pH of tested solution. Under the condition of pH 5-10, the electrodes exhibit linear response over concentration range 1.0 × 10 -7 1.0 × 10 -2