Corpus callosum and experimental stroke: studies in callosotomized rats and acallosal mice.
نویسندگان
چکیده
BACKGROUND AND PURPOSE Interhemispheric inhibition via the corpus callosum has been proposed as an exacerbating factor in outcome from stroke. METHODS We measured infarct volume and behavioral outcome after middle cerebral artery occlusion in callosotomized rats and acallosal mice. RESULTS Neither callosotomy in rats nor callosal agenesis in mice improved infarct volume or behavioral outcome after middle cerebral artery occlusion. CONCLUSIONS These findings argue against a role for transcallosal projections in exacerbating focal cerebral ischemia.
منابع مشابه
Studies in Callosotomized Rats and Acallosal Mice
Background and Purpose—Interhemispheric inhibition via the corpus callosum has been proposed as an exacerbating factor in outcome from stroke. Methods—We measured infarct volume and behavioral outcome after middle cerebral artery occlusion in callosotomized rats and acallosal mice. Results—Neither callosotomy in rats nor callosal agenesis in mice improved infarct volume or behavioral outcome af...
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ورودعنوان ژورنال:
- Stroke
دوره 42 9 شماره
صفحات -
تاریخ انتشار 2011