Analysis and Interpretation of Structure-toxicity Relationships for a Series of Organophosphorus Insecticides
نویسندگان
چکیده
Structure-toxicity relationships were studied for a set of 67 insecticides by means of multiple linear regression (MLR). The values of log LD50 (lethal dose 50, oral, rat) of the studied compounds were well correlated with the descriptors encoding the chemical structures. Considering the pertinent descriptors, a correlation coefficient of 0.87 (s = 0.42, n = 67) was obtained for the MLR model. The present study suggests a quantitative interpretation of the structure-toxicity relationships which otherwise cannot be explained within the framework of the insecticides. This information is pertinent to the further design of new insecticides.
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