C-type lectins DC-SIGN and L-SIGN mediate cellular entry by Ebola virus in cis and in trans.

نویسندگان

  • Carmen P Alvarez
  • Fátima Lasala
  • Jaime Carrillo
  • Oscar Muñiz
  • Angel L Corbí
  • Rafael Delgado
چکیده

Ebola virus is a highly lethal pathogen responsible for several outbreaks of hemorrhagic fever. Here we show that the primate lentiviral binding C-type lectins DC-SIGN and L-SIGN act as cofactors for cellular entry by Ebola virus. Furthermore, DC-SIGN on the surface of dendritic cells is able to function as a trans receptor, binding Ebola virus-pseudotyped lentiviral particles and transmitting infection to susceptible cells. Our data underscore a role for DC-SIGN and L-SIGN in the infective process and pathogenicity of Ebola virus infection.

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عنوان ژورنال:
  • Journal of virology

دوره 76 13  شماره 

صفحات  -

تاریخ انتشار 2002