Effects on HeLa cell division of physiologic deoxyribonucleosides and deoxyribonucleotides.

Adenosine but not cytidine at 2 HIMdelayed metaphase some what. Nucleolar reconstruction was retarded in cells after treatment with adenosine, deoxyadenosine, and certain combinations of agents including deoxyribonueleosides. A nucleolar change resembling that induced by adenosine or 6-thioguanine was produced in interphasic cells by a combina tion of deoxyadenosine, deoxyguanosine, and deoxycytidine-5'-