Effects of Long-term Lithium Carbonate Treatment on Thyroid Function in Psychiatric Patients
نویسندگان
چکیده
The effect of long-term lithium carbonate treatment on thyroid function was investigated in 40 clinically euthyroid patients with Manic Depressive Psychosis. Before lithium treatment, all patients showed normal levels (T(4)) of serum total thyroxine, free thyroxine index and thyrotropin (TSH). After lithium carbonate treatment for a mean period of 24 months, these patients did not show any significant change in the mean values of serum total T(4), free thyroxine index and TSH. None showed clinical symptoms of goitre and hypothyroidism after long-term lithium treatment. It is concluded that lithium therapy in euthyroid psychiatric patients has no adverse effect on thyroid function and en the pituitary secretion of TSH.
منابع مشابه
[The effect of lithium on thyroid function in patients with bipolar disorder].
Since 1963 lithium treatment has been the best proven long-term pharmacotherapy for bipolar disorder (BD), both in the prevention of depressive and manic episodes, along with the reduction of the suicide risk. Thyroid gland and the hypothalamic-pituitary-thyroid (HPT) axis play a role in the pathophysiology, clinical course and treatment of BD. The influence of lithium on the thyroid gland is o...
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Lithium carbonate is used as a first-line treatment for bipolar disorder and is given to approximately 1 in every 200 patients with this psychiatric disease. Lithium, an element in the alkali metal group, has a variety of anti-thyroid effects, primarily goiter formation and hypothyroidism. Rarely, lithium may cause hyperthyroidism secondary to thyroiditis or through possible autoimmune actions....
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Background & Aims : Bipolar Mood Disorder in acute manic episode is one of the psychiatric emergencies and usually needs to be admitted and intensive management. Treatment of these episodes ordinarily need mood stabilizer together with antipsychotic drugs. Although lithium carbonate is effective in acute mania alone, it needs more time to control episode. Only a few studies have been done a...
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