Variance and covariances of the numbers of synonymous and nonsynonymous substitutions per site.
نویسندگان
چکیده
Nei and Gojobori (1986) developed a simple method to estimate the numbers of synonymous (ds) and nonsynonymous (dN) substitutions per site. In the present paper, we have developed a method for computing variances and covariances of ds's and dN's and of the proportions of synonymous (ps) and nonsynonymous (pN) differences. We also have developed a method for computing the variances of mean dS, dN, pS, pN, without constructing a phylogenetic tree of the genes. We have conducted computer simulations based on simple evolutionary models and have shown that the new method gives good estimates of variances and covariances.
منابع مشابه
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ورودعنوان ژورنال:
- Molecular biology and evolution
دوره 11 4 شماره
صفحات -
تاریخ انتشار 1994