System Journal of Renin-angiotensin-aldosterone Journal of Renin-angiotensin-aldosterone System Long-term (6 Months) Treatment and Withdrawal in Patients with Hypertension Comparative Effects of Aliskiren-based and Ramipril-based Therapy on the Renin System during Journal of Renin-angiotensin-aldosterone System Additional Services and Information For
نویسندگان
چکیده
http://jra.sagepub.com/content/10/3/157 The online version of this article can be found at: DOI: 10.1177/1470320309342407 2009 10: 157 originally published online 17 July 2009 Journal of Renin-Angiotensin-Aldosterone System Deborah L Keefe Karl Andersen, Myron H Weinberger, Christian M Constance, Mohammed A Ali, James Jin, Margaret F Prescott and long-term (6 months) treatment and withdrawal in patients with hypertension Comparative effects of aliskiren-based and ramipril-based therapy on the renin system during
منابع مشابه
Long-term effects of aliskiren on blood pressure and the renin-angiotensin-aldosterone system in hypertensive hemodialysis patients
OBJECTIVE The long-term effects of aliskiren in hypertensive hemodialysis patients remain to be elucidated. DESIGN In this post hoc analysis, we followed up 25 hypertensive hemodialysis patients who completed 8-week aliskiren treatment in a previous study for 20 months to investigate the blood pressure-lowering effect and inhibitory effect on the renin-angiotensin-aldosterone system. RESULT...
متن کاملPredictive Modeling of Phenylpiperazine Derivatives for Renin Inhibition.
The renin–angiotensin–aldosterone system is the well established endocrine system having significant role in preserving hemodynamic stability. Renin is secreted from the juxtaglomerular cells of the kidney. Phenylpiperazine derivatives have been reported as human renin inhibitor. To perform predictive QSAR modeling for 27 phenylpiperazine derivatives as renin enzyme inhibitors. The IC50 values ...
متن کاملRenoprotection, renin inhibition, and blood pressure control: the impact of aliskiren on integrated blood pressure control
Hypertension (HTN) is an important factor in progressive loss of renal function. The kidney can be both a contributor to and a target of HTN. The functional integrity of the kidney is vital for the maintenance of cardiovascular homeostasis. Chronic activation of the renin system causes HTN and, ultimately, end-organ damage. Direct renin inhibitors (DRIs) inhibit plasma renin activity (PRA), the...
متن کاملDirect renin inhibition with aliskiren in hypertension and target organ damage.
The Joint National Committee and the World Health Organization are in agreement that hypertension in most patients who are treated is controlled inadequately and that rates of cardiovascular morbidity remain high. Additional pharmacologic treatments could ameliorate this situation. The renin-angiotensin-aldosterone system has been a highly successful pharmacologic target, as the system is stron...
متن کاملResveratrol Suppresses Cardiac Renin Angiotensin System in the Late Phase of Left Ventricular Hypertrophy
Background and objectives: Resveratrol(3,5,4′-trihydroxy-trans-stilbene) is a natural polyphenole phytoalexin which exerts potential cardioprotective effects, but the cellular and molecular mechanisms responsible for these effects are still unknown. Cardiac renin angiotensin system (RAS) over-activation plays an important role in pathogenesis of left ventricula...
متن کامل