K. Roy George
نویسندگان
چکیده
Monosodium glutamate (MSG) is one of the commonest food additives in the developed world and it is a commonly used flavour enhancer. MSG can be found in various concentrations in numerous food products. MSG is a sodium salt of glutamic acid, a naturally occurring non-essential amino acid with trade names such as Ajinomoto, Vetsin, Ac’cent and Tasting Powder. Although, MSG could improve the palatability of foods by exerting a positive influence on the appetite centre, it increased body weight (Egbuonu et al., 2010) and adversely affected locomotor activities (Eweka and Om’Iniabohs, 2008) and the testis, causing significant oligozoospermia and abnormal sperm morphology in male Wistar rats (Onakewhor et al., 1998). It has also been established that MSG may be implicated in cases of male infertility as it causes testicular hemorrhage, degeneration and alteration of sperm cell population and morphology (Oforofuo et al., 1997). Olney and Sharpe (1969) reported hypothalamic lesions, stunted skeletal development, obesity, and female sterility, as well as a spate of observed pathological changes found in several brain regions associated with endocrine function in maturing mice which had been given GLU as neonates. Neuronal and endocrine dysfunction or abnormalities in growth and behavior induced by MSG have been noted in number of animal studies, but little is known from when it is administered orally in pregnant rats. Moreover, the great similarity and homology among the genomes of the rodents and of the humans turn the animal models into an important tool for the study of conditions that affect us and that can be simulated in rats. Therefore, the present study was designed to evaluate the effects of oral administration of MSG in the fetuses of female rats during the pregnancy period.
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