AMA Series : Hi , I ’ m Warren Grill and we used computational evolution to design new patterns of deep brain stimulation to treat symptoms of Parkinson ’ s disease
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چکیده
1. Under what conditions would DBS be preferable to conventional PD therapy: L-DOPA + antipsychotic (i.e. Nuplazid)? It seems to me that the surgery must carry with it substantial risks (it is brain surgery after all). In trials of DBS, what fraction of patients see a benefit? What is the clinical meaningfulness of this benefit? And how does it weigh against the risks of the surgery and other REDDIT
منابع مشابه
Optimized temporal pattern of brain stimulation designed by computational evolution.
Brain stimulation is a promising therapy for several neurological disorders, including Parkinson's disease. Stimulation parameters are selected empirically and are limited to the frequency and intensity of stimulation. We varied the temporal pattern of deep brain stimulation to ameliorate symptoms in a parkinsonian animal model and in humans with Parkinson's disease. We used model-based computa...
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Mechanisms of Deep Brain Stimulation for the Treatment of Parkinson’s Disease: Evidence from Experimental and Computational Studies by Rosa Qi Yue So Department of Biomedical Engineering Duke University Date:_______________________ Approved: ___________________________ Warren M. Grill, Supervisor ___________________________ Roger C. Barr ___________________________ Craig S. Henriquez __________...
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Deep brain stimulation (DBS) is known as the most effective technique in the treatment of neurodegenerative diseases, especially Parkinson disease (PD) and epilepsy. Relative healing and effective control of disease symptoms are the most significant reasons for the tangible tendency in use and development of this technology. Nevertheless, more cellular and molecular investigations are required ...
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Abstract Background: To improve the debilitating features of Parkinson disease (PD) different medical and surgical approaches are available. Subthalamic nucleus deep brain stimulation (STN-DBS) was appeared to be a promising method during last two decades. This study aimed to evaluate early motor outcomes of this procedure in first trial of Iranian patients . Methods: Thirty-seven...
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