Abstract: 8.40 Intra-Graft Injection Of Tacrolimus May Modulate Local Immune Response Promoting Long-Term Acceptance Of Vca In A Modified Brown Norway To-Lewis Transplantation Model

نویسندگان

  • Radu Olariu
  • Adriano Taddeo
  • Frank Marie LeclÊRe
  • Mihai Adrian Constantinescu
  • Esther VÖGelin
چکیده

back-bone) metabolism were significantly higher after SNMP: ribose (.22-folds, p<0.001), ribonate (.37-folds, p<0.001), and ribitol (.10.5-folds, p<0.001). Glycolysis metabolites increased during SNMP: glucose-6-phosphate (.23-folds, p=0.01), fructose-6-phosphate (.12-folds, p=0.03), and phosphorenolpyruvate (.8-folds, p=0.03). Antioxidant pathways were fully functional after SNMP: glutathione-cysteine disulfide (.5.6-folds, p=0.01) and N-acetylcysteine (.40-folds, p=0.007). Energyrelated metabolites were significantly higher in SNMP flaps: cAMP (.3.7-folds, p=0.02) and adenosine (.129-fold, p=0.002).

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عنوان ژورنال:

دوره 5  شماره 

صفحات  -

تاریخ انتشار 2017