DTI Analysis of Presbycusis Using Voxel-Based Analysis.
نویسندگان
چکیده
BACKGROUND AND PURPOSE Presbycusis is the most common sensory deficit in the aging population. A recent study reported using a DTI-based tractography technique to identify a lack of integrity in a portion of the auditory pathway in patients with presbycusis. The aim of our study was to investigate the white matter pathology of patients with presbycusis by using a voxel-based analysis that is highly sensitive to local intensity changes in DTI data. MATERIALS AND METHODS Fifteen patients with presbycusis and 14 age- and sex-matched healthy controls were scanned on a 3T scanner. Fractional anisotropy, mean diffusivity, axial diffusivity, and radial diffusivity were obtained from the DTI data. Intergroup statistics were implemented on these measurements, which were transformed to Montreal Neurological Institute coordinates by using a nonrigid image registration method called large deformation diffeomorphic metric mapping. RESULTS Increased axial diffusivity, radial diffusivity, and mean diffusivity and decreased fractional anisotropy were found near the right-side hearing-related areas in patients with presbycusis. Increased radial diffusivity and mean diffusivity were also found near a language-related area (Broca area) in patients with presbycusis. CONCLUSIONS Our findings could be important for exploring reliable imaging evidence of presbycusis and could complement an ROI-based approach.
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ورودعنوان ژورنال:
- AJNR. American journal of neuroradiology
دوره شماره
صفحات -
تاریخ انتشار 2016