Effect of sodium azide on radiation damage and photoreactivation.

نویسندگان

  • H BERGER
  • F L HASS
  • O WYSS
  • W S STONE
چکیده

During investigations on the role of bacterial pigments in ultraviolet irradiation damage and in photoreactivation, several agents were tested as suppressors of pigmentation effects. Chromobacterium violaceum is extremely radiosensitive in that it shows very high inactivation by ultraviolet and also high photorecovery with white light. Sodium azide depresses both of these effects significantly. Previously, Wyss et al. (1948) demonstrated an increase in the mutation rate of Micrococcus pyogenes var. aureuw, grown in the presence of subinhibitory concentrations of this compound, and Clark et al. (1950) were able to stimulate recombination in Escherichia coli, strain K-12, under the same conditions. On the other hand, Bacq and Herve (1951) report a protective effect of azide and other respiratory poisons against X-ray damage in mice. A correlation of these effects with the known inhibitory action of azide on various iron-porphyrin enzymes appears evident, and an investigation of its applicability to other systems seemed to warrant testing on a broader basis.

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عنوان ژورنال:
  • Journal of bacteriology

دوره 65 5  شماره 

صفحات  -

تاریخ انتشار 1953