Calcium phosphate nanoparticles: Nanocrystalline bone substitution materials and carriers of nucleic acids into cells
نویسنده
چکیده
162 ©2011 Society For Biomaterials
منابع مشابه
Glutamine-chitosan modified calcium phosphate nanoparticles for efficient siRNA delivery and osteogenic differentiation.
RNA interference (RNAi)-based therapy using small interfering RNA (siRNA) exhibits great potential to treat diseases. Although calcium phosphate (CaP)-based systems are attractive options to deliver nucleic acids due to their good biocompatibility and high affinity with nucleic acids, they are limited by uncontrollable particle formation and inconsistent transfection efficiencies. In this study...
متن کاملSimilar healthy osteoclast and osteoblast activity on nanocrystalline hydroxyapatite and nanoparticles of tri-calcium phosphate compared to natural bone
While there have been numerous studies to determine osteoblast (bone forming cell) functions on nanocrystalline compared to micron crystalline ceramics, there have been few studies which have examined osteoclast activity (including tartrate-resistant acid phosphatase, formation of resorption pits, size of resorption pits, and receptor activator of nuclear factor κB [RANK]). This is despite the ...
متن کاملEffect of Graphene Oxide Nanoparticles Addition on Mechanical and Biological Properties of Calcium Phosphate Cement
In the present study, we have evaluated the effects of graphene oxide (GO) addition on the physical-mechanical-biological properties of calcium phosphate cement (CPC). The in vitro cellular responses of MG63 and in vivo tissue responses after the implantation of CPC/GO in parietal bone defects of wistar rats were also investigated. The brushite calcium phosphate cements were prepared by mixi...
متن کاملGlycosylated carriers for cell-selective and nuclear delivery of nucleic acids.
Targeted gene delivery via selective cellular receptors has been realized as a crucial strategy for successful gene therapy by maximizing therapeutic efficiency in target cells and minimizing systemic toxicity. The membrane carbohydrate-binding proteins (membrane lectins) with different carbohydrate specificities are differentially expressed on the cellular and intracellular membranes of a numb...
متن کاملBiomimetic nanocrystalline apatites: Emerging perspectives in cancer diagnosis and treatment.
Nanocrystalline calcium phosphate apatites constitute the mineral part of hard tissues, and the synthesis of biomimetic analogs is now well-mastered at the lab-scale. Recent advances in the fine physico-chemical characterization of these phases enable one to envision original applications in the medical field along with a better understanding of the underlying chemistry and related pharmacologi...
متن کامل