Non-iminosugar glucocerebrosidase small molecule chaperones.
نویسندگان
چکیده
Small molecule chaperones are a promising therapeutic approach for the Lysosomal Storage Disorders (LSDs). Here, we report the discovery of a new series of non-iminosugar glucocerebrosidase inhibitors with chaperone capacity, and describe their structure activity relationship (SAR), selectivity, cell activity phamacokinetics.
منابع مشابه
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ورودعنوان ژورنال:
- MedChemComm
دوره 3 1 شماره
صفحات -
تاریخ انتشار 2012