Development and Evaluation of Metoprolol Tartrate Chronotherapeutic Drug Delivery System

In the present research work pulsatile drug delivery system of Metoprolol tartrate tablets were formulated and developed by employing compression coating technology. Initially the core tablets were prepared by using various concentrations of super disintegrates, the formulated core tablets were coated with the polymers by using compression coating technology. All the core and press coated tablet formulations were subjected to various physical and chemical evaluation tests for core and press coated tablets. The thickness, hardness and weight variation shown by all the tablet formulations were found within the official pharmacopoeial limits. In vitro release of Metoprolol tartrate core tablet formulations F1-F3were conducted, F1 showed faster drug release after 20 min. faster drug release can be correlated with the high disintegration and friability observed in this study. The pulsatile formulations C1, C2, and C3 showed maximum drug release after 3 hour. C5 and C9 showed maximum drug release after 8th hr. Time dependent pulsatile drug delivery system has been achieved from tablet of formulation C5 and C9 with 98.37% and 99.9%.