Hydrogen sulfide : a novel gaseous signaling molecule and intracellular Ca 2 + regulator in 1 rat parotid acinar cells
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چکیده
Hydrogen sulfide: a novel gaseous signaling molecule and intracellular Ca regulator in 1 rat parotid acinar cells 2 3 Amira Moustafa1,2 and Yoshiaki Habara1 4 Laboratory of Physiology, Department of Biomedical Sciences, Graduate School of 5 Veterinary Medicine, Hokkaido University, Sapporo 060-0818, Japan; Department of 6 Physiology, Faculty of Veterinary Medicine, Zagazig University, Zagazig 44519, Egypt. 7 8 Corresponding Author: Y. Habara 9 Laboratory of Physiology, Department of Biomedical Sciences, Graduate School of 10 Veterinary Medicine, Hokkaido University, Sapporo 060-0818, Japan. 11 Phone: +81-11-706-5199 12 FAX: +81-11-706-5202 13 E-mail: [email protected] 14 15 Running title: H2S-INDUCED NITRIC OXIDE PRODUCTION AND Ca INCREASE 16 17 Articles in PresS. Am J Physiol Cell Physiol (July 29, 2015). doi:10.1152/ajpcell.00147.2015
منابع مشابه
Hydrogen sulfide: a novel gaseous signaling molecule and intracellular Ca regulator in rat parotid acinar cells
Moustafa A, Habara Y. Hydrogen sulfide: a novel gaseous signaling molecule and intracellular Ca regulator in rat parotid acinar cells. Am J Physiol Cell Physiol 309: C480–C490, 2015. First published July 29, 2015; doi:10.1152/ajpcell.00147.2015.—In addition to nitric oxide (NO), hydrogen sulfide (H2S) is recognized as a crucial gaseous messenger that exerts many biological actions in various ti...
متن کاملHydrogen sulfide: a novel gaseous signaling molecule and intracellular Ca2+ regulator in rat parotid acinar cells.
In addition to nitric oxide (NO), hydrogen sulfide (H2S) is recognized as a crucial gaseous messenger that exerts many biological actions in various tissues. An attempt was made to assess the roles and underlying mechanisms of both gases in isolated rat parotid acinar cells. Ductal cells and some acinar cells were found to express NO and H2S synthases. Cevimeline, a muscarinic receptor agonist ...
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Moustafa A, Habara Y. A novel role for carbon monoxide as a potent regulator of intracellular Ca and nitric oxide in rat pancreatic acinar cells. Am J Physiol Cell Physiol 307: C1039–C1049, 2014. First published September 24, 2014; doi:10.1152/ajpcell.00252.2014.—Carbon monoxide (CO) is known as an essential gaseous messenger that regulates a wide array of physiological and pathological process...
متن کاملA novel role for carbon monoxide as a potent regulator of intracellular Ca2+ and nitric oxide in rat pancreatic acinar cells.
Carbon monoxide (CO) is known as an essential gaseous messenger that regulates a wide array of physiological and pathological processes, similar to nitric oxide (NO) and hydrogen sulfide. The aim of the present study was to elucidate the potential role of CO in Ca(2+) homeostasis and to explore the underlying mechanisms in pancreatic acinar cells. The exogenous application of a CO-releasing mol...
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Previous reports suggested that there is no significant difference in the binding affinity of pilocarpine and cevimeline on muscarinic receptors (1). However, in vivo studies from our laboratory suggested that pilocarpine-induced salivation from the parotid gland is greater than that induced by cevimeline in rats. Therefore, in the present study, sialogogue-induced intracellular Ca(2+) mobiliza...
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