DNaseR: DNase I footprinting analysis of DNase-seq data
نویسنده
چکیده
The combination of DNase I digestion and high-throughput sequencing (DNaseseq) has been used recently to map chromatin accessibility in a given tissue or cell type on a genome-wide scale (Song and Crawford, 2010). In addition to DNase I hypersensitive sites (DHSs), short regions of protected nucleotides known as footprints can be detected using a technique known as ”digital genomic footprinting” (DGF). These analyses potentially indicate the location of transcription factor binding ocuppancy events (Neph et al., 2012). However, available software for DGF analysis is still at a very immature state (Madrigal and Krajewski, 2012).
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