Rola szlaku Hippo w kontroli proliferacji komórkowej i wielkości narządów oraz jego zaburzenia w chorobach nowotworowych* Role of the Hippo pathway in cell proliferation and organ size control. Disorders of the pathway in cancer diseases
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چکیده
The Hippo pathway (also known as SWH – Salvador/Warts/Hippo), discovered for the first time in Drosophila melanogaster, is responsible for cell proliferation and organ size control in mammalian systems. The components of the pathway are two kinases and their adaptor proteins which inhibit the transcription co-activator YAP by phosphorylation. When the pathway is inactive (as an effect of upstream component gene expression disorders), activated YAP is Streszczenie
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Investigating the mRNA expression levels of Hippo pathway in adenoma polyps
Background Neoplastic adenomatous polyps generating from the epithelial cells are considered benign tumors. Adenomatous polyps are common in western countries and it can take seven to 10 or more years for an adenoma to evolve into cancer. The Hippo signaling pathway, also known as the Salvador-Warts-Hippo (SWH) pathway, is a signaling pathway that controls organ size in animals through the r...
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The control of cell division is essential for normal development and the maintenance of cellular homeostasis. Abnormal cell proliferation is associated with multiple pathological states, including cancer. Although the Hippo/YAP signaling pathway was initially thought to control organ size and growth, increasing evidence indicates that this pathway also plays a major role in the control of proli...
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Two decades of studies in multiple model organisms have established the Hippo pathway as a key regulator of organ size and tissue homeostasis. By inhibiting YAP and TAZ transcription co-activators, the Hippo pathway regulates cell proliferation, apoptosis, and stemness in response to a wide range of extracellular and intracellular signals, including cell-cell contact, cell polarity, mechanical ...
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