Tubulin family: Kinship of key proteins across phylogenetic domains
نویسنده
چکیده
Atomic structures obtained by electron microscopy for tubulin, and by X-ray crystallography for bacterial FtsZ, show that the two proteins are highly homologous. The complementarity between such high-resolution studies and low-resolution reconstructions of microtubule complexes is clear, but controversy still abounds.
منابع مشابه
XMAP215 polymerase activity is built by combining multiple tubulin-binding TOG domains and a basic lattice-binding region.
XMAP215/Dis1 family proteins positively regulate microtubule growth. Repeats at their N termini, called TOG domains, are important for this function. While TOG domains directly bind tubulin dimers, it is unclear how this interaction translates to polymerase activity. Understanding the functional roles of TOG domains is further complicated by the fact that the number of these domains present in ...
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ورودعنوان ژورنال:
- Current Biology
دوره 8 شماره
صفحات -
تاریخ انتشار 1998