Aman Kumar
نویسندگان
چکیده
Catecholamines are the common name used for the hormones like epinephrine (adrenaline), norepinephrine (noradrenaline), and dopamine. Catecholamines are neurotransmitters which are involved in various regulatory processes and its involvement in various disorders like cardiovascular, neurological, psychiatric has been extensively studied. The qualitative dynamics of the catecholamine synthesis and degradation pathway is studied here using synchronous and asynchronous analysis with the help of Boolean modelling. The effect of various inhibitors on the key enzyme viz. Monoamine oxidase (MAO) of the degradation pathway was also studied and the network was validated. The results obtained gives an important insight into the state cycle and steady state of the catecholamine regulatory network.
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