Protection of Mycobacterium smegmatis from Ethambutol and Streptomycin Inhibition by MgSO(4) and Polyamines.
نویسندگان
چکیده
Polyamines protected Mycobacterium smegmatis from ethambutol inhibition but not from streptomycin inhibition, whereas MgSO(4) neutralized growth inhibition by both drugs.
منابع مشابه
Nonspecific ionic inhibition of ethambutol binding by Mycobacterium smegmatis.
Magnesium sulfate and spermidine were tested for their effects on binding of (14)C-ethambutol by Mycobacterium smegmatis. Concentrations were used that protected the organism from ethambutol inhibition. Sodium salts were examined as possible ethambutol antagonists to test the previously reported specificity of the divalent cation salt effect. Consistent with growth-protection experiments, 20 mM...
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Forbes, M. (Lederle Laboratories Division, Pearl River, N.Y.), N. A. Kuck, and E. A. Peets. Effect of ethambutol on nucleic acid metabolism in Mycobacterium smegmatis and its reversal by polyamines and divalent cations. J. Bacteriol. 89:1299-1305. 1965.-Mycobacterium smegmatis, harvested from cultures inhibited by ethambutol and then suspended in drug-free medium, exhibited a prolonged lag befo...
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We have examined and compared the effects of monovalent and divalent cation salts on dihydrostreptomycin (DSM) action against Mycobacterium smegmatis. The Sauton synthetic liquid medium used was supplemented with test salts on the basis of ionic strength (mu). Turbidimetric growth experiments showed that 0.02 M MgSO(4) (mu = 0.08) prevented growth inhibition by 0.1 mug of dihydrostreptomycin pe...
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Treatment of either Mycobacterium tuberculosis or M. smegmatis with ethambutol results both in inhibition of arabinan synthesis and in copious loss of previously formed arabinan from the cell wall. The loss of arabinan has been shown to be due to the action of an endogenous arabinase. To better understand this phenomenon, a quantitative assay for endogenous arabinase was developed. Using the as...
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ورودعنوان ژورنال:
- Infection and immunity
دوره 3 3 شماره
صفحات -
تاریخ انتشار 1971