Mannosyl glycodendritic structure inhibits DC-SIGN-mediated Ebola virus infection in cis and in trans.

نویسندگان

  • Fátima Lasala
  • Eva Arce
  • Joaquín R Otero
  • Javier Rojo
  • Rafael Delgado
چکیده

We have designed a glycodendritic structure, BH30sucMan, that blocks the interaction between dendritic cell-specific intercellular adhesion molecule 3-grabbing nonintegrin (DC-SIGN) and Ebola virus (EBOV) envelope. BH30sucMan inhibits DC-SIGN-mediated EBOV infection at nanomolar concentrations. BH30sucMan may counteract important steps of the infective process of EBOV and, potentially, of microorganisms shown to exploit DC-SIGN for cell entry and infection.

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عنوان ژورنال:
  • Antimicrobial agents and chemotherapy

دوره 47 12  شماره 

صفحات  -

تاریخ انتشار 2003