No association between cytochrome P450 and glutathione S-transferase gene polymorphisms and risk of colorectal adenoma: results from the UK Flexible Sigmoidoscopy Screening Trial.
نویسندگان
چکیده
Dunn Human Nutrition Unit, Medical Research Council, Cambridge, United Kingdom; Department of General Surgery, Norfolk and Norwich Health Care NHS Trust, Norwich, United Kingdom; Cancer Sciences Division, University of Southampton, Southampton, United Kingdom; Cancer Research UK Genetic Epidemiology Division, St James’s University Hospital, Leeds, United Kingdom; and Cancer Research UK, St Mark’s Hospital, Harrow, United Kingdom
منابع مشابه
Null Results in Brief No Association between Cytochrome P450 and Glutathione S-Transferase Gene Polymorphisms and Risk of Colorectal Adenoma: Results from the UK Flexible Sigmoidoscopy Screening Trial
Dunn Human Nutrition Unit, Medical Research Council, Cambridge, United Kingdom; Department of General Surgery, Norfolk and Norwich Health Care NHS Trust, Norwich, United Kingdom; Cancer Sciences Division, University of Southampton, Southampton, United Kingdom; Cancer Research UK Genetic Epidemiology Division, St James’s University Hospital, Leeds, United Kingdom; and Cancer Research UK, St Mark...
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Cigarette smoking is a risk factor for colon adenoma. The glutathione S-transferase enzymes are involved in the detoxification of carcinogenic compounds including those found in tobacco smoke, and thus, may be important modifiers of individual risk of developing this disease. We examined the prevalence of GSTM1 and GSTT1 gene deletions, and two GSTP1 polymorphisms in 772 cases with advanced col...
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Associations of functional single nucleotide polymorphisms in cytochrome P450 1B1, epoxide hydrolase 1, NAD(P)H:quinone oxidoreductase 1, glutathione S-transferase Pi-1 and deletions of glutathione S-transferases Mu-1 and θ-1 with colorectal cancer risk were investigated in a hospital-based case-control study on 495 matched pairs of Czech Caucasians. Polymorphisms were assessed by polymerase ch...
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Currently several studies are being carried out on various properties of mesenchymal stem cells (MSCs)however there are a few investigations about drug metabolizing properties of these cells. The aim of thisstudy was to measure the key factors involved in drug metabolism in human bone marrow MSCs. For thispurpose, cellular glutathione (GSH), glutathione Stransferase (GSTs) and...
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Background: Cytochrome P450 2C19 (CYP2C19) is widely involved in the metabolism of some medications. On the other hand, recent studies have shown the contribution of the CYP2C19 polymorphisms to different malignancies. We aimed to investigate the association between CYP2C19 polymorphism and occurrence of hematological malignancies by comparing the phenotype distribution of this enzyme in patien...
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ورودعنوان ژورنال:
- Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
دوره 14 4 شماره
صفحات -
تاریخ انتشار 2005