Antibiofilm Peptide Development for Clinical and Industrial Applications
نویسنده
چکیده
Natural Antimicrobial peptides (AMPs) are important components of immune systems and possess immuno-modulatory and broad spectrum antimicrobial activities. These host-defense peptides failed to resist protease degradation or to efficiently inhibit biofilm formation. We describe in this review the different strategies to improve AMPs and develop peptides that could be used clinically and in industry through antimicrobial, antibiofilm and/or anti-inflammatory activities, protease resistant property and without being cytotoxic. They can be developed as free molecules or immobilized on surfaces or in synergy with other treatments. AMPs could be the next important step in bacteriology treatment after antibiotic discovery.
منابع مشابه
Antibiofilm Activity of Actinobacillus pleuropneumoniae Serotype 5 Capsular Polysaccharide
Cell-free extracts isolated from colony biofilms of Actinobacillus pleuropneumoniae serotype 5 were found to inhibit biofilm formation by Staphylococcus aureus, S. epidermidis and Aggregatibacter actinomycetemcomitans, but not by A. pleuropneumoniae serotype 5 itself, in a 96-well microtiter plate assay. Physical and chemical analyses indicated that the antibiofilm activity in the extract was d...
متن کاملThe National Conference on Protein & Peptide Sciences: From Basic to Medical & Industrial Applications (Shiraz University 10 & 11 December 2014)
متن کامل
Antimicrobial, antibiofilm, and microbial barrier properties of poly (ε-caprolactone)/cloisite 30B thin films
Development of antibacterial and antibiofilm surfaces is in high demand. In this study, nanocomposite of Poly (ε-caprolactone)/Cloisite 30B was prepared by the solvent casting method. The membranes were characterised by SEM, AFM, and FTIR. Evaluation of water uptake, antimicrobial, antibiofilm, and microbial barrier properties demonstrated a significant antimicrobial and antibiofilm activity ag...
متن کاملReal-Time Assessment of Staphylococcus aureus Biofilm Disruption by Phage-Derived Proteins
A current focus of research is the development of new tools for removing bacterial biofilms in industrial settings. Bacteriophage-encoded proteins, such as endolysins, virion-associated peptidoglycan hydrolases, and exopolysaccharide depolymerases, have been shown to be efficient against these structures. However, the current screening techniques for the identification of antibiofilm properties...
متن کاملProduction, quality control and imaging of 64Cu-ATSM in healthy rabbits for clinical applications
Introduction: [64Cu]diacetyl-bis(N4-methylthiosemicarbazone) ([64Cu]ATSM) is a well-established hypoxia imaging tracer with reproducible production and significant specifity. In this work the high yield production and quality control as well as imaging studies in healthy rabbits is reported. Methods: Copper-64 produced ...
متن کامل