Gold(I)-Catalyzed Activation of Alkynes for the Construction of Molecular Complexity
نویسندگان
چکیده
منابع مشابه
Anti-Markovnikov hydroimination of terminal alkynes in gold-catalyzed pyridine construction from ammonia.
Gold-catalyzed hydroimination of terminal alkynes, giving rise to anti-Markovnikov adducts concomitant with unstable Markovnikov adducts is described. The elementary step can be applied for the construction of pyridine derivatives from ammonia and alkynes.
متن کاملSynthesis of indenyl ethers by gold(I)-catalyzed intramolecular carboalkoxylation of alkynes.
The gold(I)-catalyzed carboalkoxylation of alkynes to form indanone derivatives from readily available ortho-acetylenic benzylic ethers is described. Importantly, the gold(I)-catalyzed rearrangement of enantioenriched benzylic ethers proceeds with chirality transfer, thus providing a practical method for the enantioselective synthesis of indenyl ethers.
متن کاملGold(I)-catalyzed 5-endo-dig carbocyclization of acetylenic dicarbonyl compounds.
The importance of cyclopentanoid natural products continues to inspire the development of methods for the synthesis of 5-membered rings. For example, the Conia–ene reaction provides an atomeconomical synthesis of methylenecyclopentanes by the thermal cyclization of e-acetylenic carbonyl compounds. While the classic thermal reaction is limited to the exocyclic cyclization mode, group 6 metal com...
متن کاملSyntheses of α-Pyrones Using Gold-Catalyzed Coupling Reactions
Sequential alkyne activation of terminal alkynes and propiolic acids by gold(I) catalysts yields compounds having α-pyrone skeletons. Novel cascade reactions involving propiolic acids are reported that give rise to α-pyrones with different substitution patterns.
متن کاملAnomalous ligand effect in gold(I)-catalyzed intramolecular hydroamination of alkynes.
We analyzed the ligand electronic effect in a gold(I)-catalyzed intramolecular alkyne hydroamination, through a DFT and charge-displacement function (CDF) study. We found that, in the presence of π-electron conjugation between the alkyne and the nucleophilic functionality, electron poor ligands modify the coordination mode and the geometric parameters of the substrate in such a way that, contra...
متن کامل