Sedation depth and mortality in mechanically ventilated critically ill adults
نویسندگان
چکیده
A Prospective Longitudinal Multicentre Cohort Study Y. Shehabi 1, S. Kadiman 2, L. Chan 3 , W. N. W. Ismail 4, M. A. Saman 5, A. Alias 6 For the Sedation Practice in Intensive Care Evaluation Study Group, the MY SPICE Study investigators Author Affiliations: 1 Prince of Wales Hospital, University New South Wales, 2 National Heart Institute Kuala Lumbar,3 University Malaya Medical Center 4 Hospital Raja Perempuan Zainab II , Kota Bahru, 5 Sarawak General Hospital – Kuching, 6 Hospital Melaka Melaka # 323
منابع مشابه
Benzodiazepine versus nonbenzodiazepine-based sedation for mechanically ventilated, critically ill adults: a systematic review and meta-analysis of randomized trials.
BACKGROUND Use of dexmedetomidine or propofol rather than a benzodiazepine sedation strategy may improve ICU outcomes. We reviewed randomized trials comparing a benzodiazepine and nonbenzodiazepine regimen in mechanically ventilated adult ICU patients to determine if differences exist between these sedation strategies with respect to ICU length of stay, time on the ventilator, delirium prevalen...
متن کاملPharmacokinetics Alterations of Midazolam Infusion versus Bolus Administration in Mechanically Ventilated Critically Ill Patients
There is no randomized study carried out in order to compare their pharmacokinetic parameters although midazolam, as a sedative, has been widely administered via continuous infusion as well as intermittent bolus doses in mechanically ventilated critically ill patients. We prospectively investigated the effect of these two principal methods on pharmacokinetic parameters in 23 of mentioned patien...
متن کاملThe SPICE III study protocol and analysis plan: a randomised trial of early goaldirected sedation compared with standard care in mechanically ventilated patients.
BACKGROUND Sedation strategy in critically ill patients who are mechanically ventilated is influenced by patient-related factors, choice of sedative agent and the intensity or depth of sedation prescribed. The impact of sedation strategy on outcome, in particular when delivered early after initiation of mechanical ventilation, is uncertain. OBJECTIVES To present the protocol and analysis plan...
متن کاملEarly sedation use in critically ill mechanically ventilated patients: when less is really more
Over the last 10 years, there has been an explosion of literature surrounding sedation management for critically ill patients. The clinical target has moved away from an unconscious and immobile patient toward a goal of light or no sedation and early mobility. The move away from terms such as 'sedation' toward more patient-centered and symptom-based control of pain, anxiety, and agitation makes...
متن کاملPharmacokinetics Alterations of Midazolam Infusion versus Bolus Administration in Mechanically Ventilated Critically Ill Patients
There is no randomized study carried out in order to compare their pharmacokinetic parameters although midazolam, as a sedative, has been widely administered via continuous infusion as well as intermittent bolus doses in mechanically ventilated critically ill patients. We prospectively investigated the effect of these two principal methods on pharmacokinetic parameters in 23 of mentioned patien...
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